Malaria parasite invasion of human red blood cells and the insights we can obtain from 4D imaging

Associate Professor Kelly Rogers is Head of the Advanced Technology and Biology Division and the Centre for Dynamic Imaging at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia. After completing a PhD at Griffith University, she undertook postdoctoral training at the Institut Pasteur in Paris before returning to Australia in 2009 to establish the Centre for Dynamic Imaging (CDI) at WEHI. In 2017 A/Prof. Rogers was appointed a laboratory head with a focus on the application and development of advanced microscopy methods. One of the achievements of her team has been to build a lattice light sheet microscope which was instrumental in the discovery that mitochondrial DNA is released during apoptosis through BAK and BAX pores in the outer mitochondrial membrane. Her team has also used this approach to obtain 4D volumetric data on malaria parasite infection of red blood cells to gain greater insight about the role of parasite derived proteins and force on host cell membrane and cytoskeletal reorganisation during invasion.

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