» Research » Projects » Characterisation of the virulence complex of the malaria parasite Plasmodium falciparum (ANU-Humboldt Graduate School project)
Characterisation of the virulence complex of the malaria parasite Plasmodium falciparum (ANU-Humboldt Graduate School project)
Scanning electron microscope image of a malaria parasite-infected human erythrocyte
The malaria parasite-infected human red blood cell cytoadheres to receptors on the endothelial cells in vital organs of its host by expressing virulence complex proteins on its host cell surface. These proteins traffic through parasite established organelles in the host cell, Maurer’s clefts.
In this project we will characterise the assembly and function of the individual virulence complex components in a cellular context. Techniques include generating transgenic P. falciparum cell lines, functional biochemical analytical assays and mutant characterisation by various advanced microscopy techniques.